{"id":7494,"date":"2024-08-08T11:16:58","date_gmt":"2024-08-08T15:16:58","guid":{"rendered":"https:\/\/380cebbe0d.nxcli.io\/pharmacy\/?page_id=7494"},"modified":"2024-09-19T10:26:38","modified_gmt":"2024-09-19T14:26:38","slug":"reed-lab","status":"publish","type":"page","link":"https:\/\/380cebbe0d.nxcli.io\/pharmacy\/pharmsci\/reed-lab\/","title":{"rendered":"Reed Lab"},"content":{"rendered":"

[vc_row content_width=”full” page_header_style=”normal” css=”.vc_custom_1713293111862{margin-bottom: 0px !important;background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}” el_class=”block-a”][vc_column][vc_row_inner css=”.vc_custom_1713293133775{margin-bottom: 0px !important;}”][vc_column_inner css=”.vc_custom_1713293083106{margin-bottom: 0px !important;}”][vc_raw_html]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[\/vc_raw_html][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row content_width=”full” el_class=”block-b”][vc_column][vc_row_inner gap=”10″][vc_column_inner el_class=”sidebar” width=”1\/3″ css=”.vc_custom_1713289176498{padding-top: 200px !important;}”][vc_raw_html]JTNDaW1nJTIwc3JjJTNEJTIyJTJGd3AtY29udGVudCUyRnVwbG9hZHMlMkYlMkZyZWVkLWVyaW4tMjQtMzAwLmpwZyUyMiUyMGFsdCUzRCUyMkVyaW4lMjBSZWVkJTJDJTIwUGguRC4lMjIlMjB3aWR0aCUzRCUyMjMwMCUyMiUyMGhlaWdodCUzRCUyMjM3NSUyMiUyMCUyMGxvYWRpbmclM0QlMjJsYXp5JTIyJTNF[\/vc_raw_html][vc_column_text]<\/p>\n

Principal investigator<\/h4>\n

Erin Reed, Ph.D.<\/strong>
\nAssistant Professor of Pharmaceutical Sciences
\nGraduate Faculty II College of Graduate Studies<\/span><\/p>\n

Full biography<\/a><\/p>\n

Contact<\/h4>\n

4209 St. Rt. 44, PO Box 95
\nDepartment of Pharmaceutical Sciences
\nRootstown, OH 44272<\/p>\n

ereedgeaghan@380cebbe0d.nxcli.io<\/a>
\n330-325-6438[\/vc_column_text][vc_separator color=”custom” align=”align_left” el_width=”70″ accent_color=”#c1c1c1″][\/vc_column_inner][vc_column_inner el_class=”main-body” width=”2\/3″][vc_column_text]<\/p>\n

Research focus of the Reed Lab<\/h3>\n

The Reed laboratory focuses on the inflammatory response in the brain during Alzheimer\u2019s disease (AD). Our work is based on a few important observations in humans:<\/p>\n

    \n
  1. Brain inflammation accompanies the hallmark amyloid plaque deposits, neurofibrillary tau tangles, and neuron loss of AD.<\/li>\n
  2. Many genes associated with AD have important immune functions.<\/li>\n
  3. Women make up about two-thirds of AD patients in the US.<\/li>\n
  4. There are differences in the immune systems of men and women.<\/li>\n<\/ol>\n

    We focus on how the immune system differences between men and women contribute to the different disease onset and trajectory. We use mice to model AD and to study specific immune cells in the course of disease.
    \n\"A<\/p>\n

    Current work<\/h3>\n

    Project 1<\/strong>
    \nDelineate the relative contributions of the sex chromosomes and circulating gonadal sex hormones to different inflammatory responses in the brains of AD mouse models.<\/p>\n

    Project 2<\/strong>
    \nDetermine whether hormone exposure during an important developmental time instructs immune cells to behave in specific ways before and during AD.<\/p>\n

    Project 3<\/strong>
    \nCharacterize the immune cells entering the brain and collecting at its borders, and how they communicate with each other. Compare how this may be different based on sex chromosomes and gonadal hormones, both during development and adulthood.<\/p>\n

    Open positions<\/h3>\n

    See open positions in this lab on the NEOMED careers site<\/a><\/p>\n

    Select publications<\/h3>\n

    Casali, BT, Reed-Geaghan EG. \u201cMicroglial function and regulation during development, homeostasis, and Alzheimer\u2019s disease.\u201d (2021) Cells 10 (4): 957. https:\/\/doi.org\/10.3390\/cells10040957<\/a>.<\/p>\n

    Casali BT, MacPherson KP, Reed-Geaghan EG, Landreth GE. \u201cMicroglial depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies.\u201d Neurobiology of Disease 142: 104956. https:\/\/doi.org\/10.1016\/j.nbd.2020.104956<\/a>.<\/p>\n

    Reed-Geaghan EG, Landreth GE. \u201cPlaque-associated myeloid cells derive exclusively from resident microglia in Alzheimer\u2019s disease.\u201d (2020) Journal of Experimental Medicine 217 (4): e20191374. https:\/\/doi.org\/10.1084\/jem.20191374<\/a>.<\/p>\n

    Cheng-Hathaway PJ*, Reed-Geaghan EG*, Jay TR*, Casali BT, Bemiller SM, Puntambekar SS, Karlo JC, Xu G, Ransohoff RM, Lamb BT, Landreth GE. \u201cThe Trem2 R47H variant confers a loss of TREM2 function in Alzheimer\u2019s disease.\u201d (2018) Molecular Neurodegeneration 13: 29. https:\/\/doi.org\/10.1186\/s13024-018-0262-8<\/a>
    \n*denotes these authors contributed equally to this work<\/p>\n

    Casali BT, Reed-Geaghan EG, Landreth GE. \u201cNuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in an AD mouse model.\u201d (2018) Journal of Neuroinflammation 15: 43. https:\/\/doi.org\/10.1186\/s12974-018-1091-y<\/a><\/p>\n

    Reed-Geaghan EG, Savage JC, Hise AG, Landreth GE. \u201cCD14 and Toll-like receptors 2 and 4 are required for fA\u03b2-stimulated microglial activation.\u201d (2009) J Neurosci 29:11982. https:\/\/doi.org\/10.1523\/jneurosci.3158-09.2009<\/a><\/p>\n

    Zelcer N, Khanlou N, Clare R, Jiang Q, Reed-Geaghan EG, Landreth GE, Vinters HV, Tontonoz P. \u201cAttenuation of neuroinflammation and Alzheimer\u2019s disease pathology by liver X receptors.\u201d (2007) PNAS 104:10601. https:\/\/doi.org\/10.1073\/pnas.0701096104<\/a><\/p>\n

    Select collaborators<\/h3>\n

    Previous lab members and what they are doing today<\/p>\n

    Summer Research Fellows<\/strong><\/p>\n

      \n
    • Lydia Chlpka \u2013 medical student, expected graduation May 2025<\/li>\n
    • Heleina Dopazo \u2013 medical student, expected graduation May 2025<\/li>\n
    • Emily Marsico \u2013 medical student, expected graduation May 2024<\/li>\n<\/ul>\n

      Research elective students<\/strong><\/p>\n

        \n
      • Gerald Crutchfield, Pharm.D. (2023) \u2013<\/li>\n
      • Emmanuel Livchak, Pharm.D. (2023) \u2013 PGY1 resident, Cleveland Clinic Avon<\/li>\n<\/ul>\n

        Equipment of significance<\/h3>\n

        BD FACSymphony A1 flow cytometer<\/p>\n

        Select funders<\/h3>\n
          \n
        • BrightFocus Foundation<\/li>\n
        • NIA\/NIH<\/li>\n<\/ul>\n

          Lab members today<\/h3>\n
            \n
          • Brad Casali, PhD
            \nPostdoctoral Fellow<\/li>\n
          • Phaedra Norrell Keller
            \nGraduate Student<\/li>\n
          • Hannah Zuppe
            \nGraduate Student<\/li>\n<\/ul>\n

            [\/vc_column_text][vc_empty_space height=”50px”][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row content_width=”full” css=”.vc_custom_1688392540228{background-color: #f3f1e6 !important;}”][vc_column]

            \r\n